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KMID : 0368820060450060598
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Journal of the Korean Neuropsychiatr Association
2006 Volume.45 No. 6 p.598 ~ p.603
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Modafinil Effect in Psychostimulant-Inapplicable Children with Attention Deficit Hyperactivity Disorder - Preliminary Study
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Yoo Han-Ik
Kim Jin-Yong
Park Su-Bin
Jeon Jeong-Won
Wang Hee-Ryung
Hong Jin-Pyo
Kim Seong-Yoon
Kim Chang-Yoon
Kim Bung-Nyun
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Abstract
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Objective: This study was aimed to examine the efficacy and safety of modafinil in psychostimulant-inapplicable children with attention deficit hyperactivity disorder (ADHD) due to insufficient treatment response or intolerable adverse effects.
Methods: Fifteen children (8.8+/-1.8 years, 14 boys, total IQ 107.22+/-13.4) were recruited for this study. ADHD was confirmed by K-SADS-PL. The efficacy was assessed by ADHD rating scale (ADHDRS), Conner’s parental rating scale-revised (CPRS-R), ADHDRS school version, clinical global impression (CGI) and computerized neurocognitive function test. Mean dose of modafnil was 250. 0+/-103.3 mg.
Results: Total score (p=0.012) and hyperactive/impulsive score (p=0.021) of ADHDRS for investigator, as well as CPRS-R score (p<0.01) and CGI-severity score (p<0.01) were significantly reduced after 39.2+/-8.7 days of modafinil administration. Response time of word color test was also significantly decreased after medication. Decreased appetite (2 subjects), insomnia (2 subjects), irritability (1 subject) and alopecia (1 subject) were observed during this study period.
Conclusion: Modafinil was effective and well-tolerated for the psychostimulant-inapplicable children with ADHD.
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KEYWORD
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ADHD, Modafinil
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